Personal profile
Education
o (1995) B.E., Dongguk University
o (1998) M.S., Yonsei University
o (2009) Ph.D., Yale University
Professional Experience
o (2022~Present) Professor, KAIST, Daejeon, Korea
o (2016~2022) Associate Professor, KAIST, Daejeon
o (2009~2016) Assistant Professor, KAIST, Daejeon
o (2009~2009) Postdoctoral Associate, Yale University, New Haven, CT, USA
Research interests
Brain cancer, gd T cells, Tumor microenvironment, HSV infection, Gut microbiota, Immune regulation
Major Research Achievements
o Identification of tumor hypoxia which represses γδ T cell-mediated antitumor immunity against brain tumors.
o Identification of supplementation with a high-glucose drink stimulates anti-tumor immune responses to glioblastoma via gut microbiota modulation.
o Identification of the regulation of c-SMAC formation and AKT-mTOR signaling by the TSG101-IFT20 axis in CD4+ T cells
o Identification of Obesity which enhances antiviral immunity in the genital mucosa through a microbiota-mediated effect on γδ T cells.
o Identification of blood monocyte-derived CD169+ macrophages which contribute to antitumor immunity against glioblastoma.
o Development of intranasal delivery of an adenovirus-vector vaccine co-expressing a modified spike protein and a genetic adjuvant confers lasting mucosal immunity against SARS-CoV-2.
o Identification of factors which determines the severity of COVID-19 by the analysis of single cell transcriptome
o Identification of Autophagic protein ATG5 which controls anti-viral immunity via glycolytic reprogramming of dendritic cells against respiratory syncytial virus infection.
o Development of multivalent DNA vaccine which protects against genital herpes by T-cell immune induction in vaginal mucosa.
o Identification of Autophagy protein ATG5 which regulates CD36 expression and anti-tumor MHC class II antigen presentation in dendritic cells.
o Identification of a mechanism for the induction of type 2 immune responses by a protease allergen in the genital tract.
o Identification of the role of dysbiosis-induced IL-33 which contributes to impaired antiviral immunity in the genital mucosa.
Related documents
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Collaborations and top research areas from the last five years
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Differential responses of lung and intestinal microbiota to SARS-CoV-2 infection: a comparative study of the Wuhan and Omicron strains in K18-hACE2 Tg mice
Kim, C. W., Ku, K. B., Hwang, I., Jung, H. E., Kim, K. D. & Lee, H. K., Dec 2025, In: Laboratory Animal Research. 41, 1, 11.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Gut dysbiosis from high-salt diet promotes glioma via propionate-mediated TGF-β activation
Kim, C. W., Kim, H. J., Kang, I., Ku, K. B., Kim, Y., Park, J. H., Lim, J., Kang, B. H., Park, W. H., La, J., Chang, S., Hwang, I., Kim, M., Ahn, S. & Lee, H. K., 4 Aug 2025, In: Journal of Experimental Medicine. 222, 8Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Gut microbiota dysbiosis induced by brain tumors modulates the efficacy of immunotherapy
Kim, H. C., Kim, H. J., La, J., Park, W. H., Park, S. H., Kang, B. H., Kim, Y. & Lee, H. K., 22 Jul 2025, In: Cell Reports. 44, 7, 115825.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Human γδ T cells in the tumor microenvironment: Key insights for advancing cancer immunotherapy
Park, W. H. & Lee, H. K., Feb 2025, In: Molecules and Cells. 48, 2, 100177.Research output: Contribution to journal › Review article › peer-review
Open Access8 Scopus citations -
Local delivery of IL-12 mRNA and indoximod prodrug potentiates antitumor immunity by increasing T cell effector function
Park, H., Kang, I., Lee, S., Park, M., Kim, S., Lim, S. Y., Nam, H., Yun, D., Kim, S., Kim, Y., Jeong, J. H., Lee, K., Lee, H. K., Lee, Y. K. & Kim, Y. C., 10 Sep 2025, In: Journal of Controlled Release. 385, 113970.Research output: Contribution to journal › Article › peer-review
4 Scopus citations
Press/Media
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Placental Inflammation Linked to Childhood Allergies – New Research
7/08/25
1 item of Media coverage
Press/Media
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New possibilities for treating intractable brain tumors unveiled
15/11/24
1 item of Media coverage
Press/Media