Analysis of functional MRI data using mutual information

A new information-theoretic approach is presented for analyzing fMRI data to calculate the brain activation map. The method is based on a formulation of the mutual information between two waveforms–the fMRI temporal response of a voxel and the experimental protocol timeline. Scores based on mutual information are generated for all voxels and then used to compute the activation map of an experiment. Mutual information for fMRI analysis is employed because it has been shown to be robust in quantifying the relationship between any two waveforms. More importantly, our technique takes a principled approach toward calculating the brain activation map by making few assumptions about the relationship between the protocol timeline and the temporal response of a voxel. This is important especially in fMRI experiments where little is known about the relationship between these two waveforms. Experiments are presented to demonstrate this approach of computing the brain activation map. Comparisons to other more traditional analysis techniques are made and the results are presented.